Epigeno™: Reactivating Vitality at the Genetic Level

EpigenoTM is Longevitan’s proprietary, science-driven framework designed to combat cellular aging at the source – your genes. Rooted in cutting-edge epigenetics, it identifies and modulates genetic pathways that influence aging, stress resilience and cellular repair.

By restoring NAD⁺ levels, regulating gene expression and reducing oxidative stress, EpigenoTM aims to restore biological function from the inside out – supporting mitochondrial function, boosting cellular energy, and helping the body reset its own repair systems.

This comprehensive approach promotes long-term vitality at the genetic level and forms the scientific basis for Longevitan Recharge+ supplementation.

 Epigenetic Modulation
↑NAD⁺
Mitochondrial Repair
Cellular Restoration
Why NAD⁺ Matters:

NAD⁺ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme that supports energy metabolism, DNA repair, and mitochondrial function. It plays a central role in maintaining enzymes such as sirtuins, PARP, and CD38, key regulators of longevity and cellular health.

But NAD⁺ levels naturally decline with age.

NAD⁺ loss impairs mitochondrial activity and accelerates cellular aging.

Lifestyle stressors—chronic stress, a high-sugar diet, lack of sleep—further deplete NAD⁺ stores, leading to decreased energy, slower recovery, and reduced cellular repair.

EpiGenoTM is designed to counteract this decline by restoring NAD⁺ levels and supporting the body’s natural renewal system.

The Function Of These Enzymes
1/3
1. SIRT1

Gene silencing & DNA repair

2/3
2.PARP

DNA damage sensing

3/3
3.CD38

NAD⁺ consumption

EpigenoTM in Action: Translating Science into Cellular Benefits

More than a theoretical framework, EpigenoTM is the engine behind Recharge+—translating cutting-edge science into functional, cellular benefits.

Mapping EpigenoTM Science to Function:
TRADITIONAL ORGASM
Boost NAD⁺
Combat oxidative stress
Promote mitochondrial resilience
Support inflammation balance
KEY INGREDIENT IN RECHARGE+
NR (Nicotinamide Riboside)
Anthocyanins, Lycopene
Quercetin, CoQ10
Curcumin
FUNCTION
NAD⁺ precursor for energy & repair
Antioxidant & DNA protection
Enhance mitochondrial function
Regulate cellular inflammatory response

This mechanism-to-ingredient mapping makes EpigenoTM more than a scientific idea—it’s a functional strategy to restore the conditions that support optimal gene expression, from increasing NAD⁺ to reducing oxidative damage and supporting long-term cellular health.

Aging & Stress
↓ Cellular NAD⁺ Reservoir
↓ DNA Repair Capacity & Mitochondrial Efficiency
↑ Cellular Damage & Fatigue
EpiGenoTM Reset Pathway
↑ NAD⁺ Availability
↑ Systemic Repair + ↑ Cellular Vitality
Flowchart for EpigenoTM
Clinically Backed: The Science Behind EpigenoTM

EpigenoTM is more than just a scientific framework – it’s backed by peer-reviewed clinical studies demonstrating how its core mechanisms translate into real cellular benefits.

Study 1
Chronic Nicotinamide Riboside Supplementation Elevates NAD⁺ in Healthy Adults
Design:
6-week randomized, double-blind, placebo-controlled crossover trial
Subjects:
Healthy adults aged 55–79
Result:
Around 60% Increase NAD⁺ levels in immune cells
Implication:
Validates NR as a potent NAD⁺ precursor supporting cellular energy and repair
Source:
Martens et al., Nature Communications, 2018
Study 2
The NADPARK Study: A Phase I Trial of NR Supplementation in Parkinson’s Disease
Design:
30-day randomized, double-blind, placebo-controlled clinical trial
Subjects:
Patients with early-stage Parkinson’s disease
Result:
Improved brain NAD⁺ status measured by 31P-MRS
Implication:
Demonstrates NR’s ability to influence central NAD⁺ metabolism in humans
Source:
Brakedal et al., Cell Metabolism, 2022

Together, these studies provide strong human evidence for the foundation of EpigenoTM – nutrients that restore NAD⁺ balance, enhance mitochondrial function, and protect long-term cellular health.

Real Benefits for Real Life

Recharge+ delivers science you can feel—every capsule is built to help you resist cellular aging and stay sharp through life’s demands.

Feel the difference - whether it's sharper focus, recovery after a workout, or a boost after a long day at work.

Recharge+ helps you stay energized, clear-headed, and full of energy.